| N° | FECHA HORA | CIUDAD | PARTIDOS | ARBITRO | ARB. ASIST. 1 | ARB. ASIST. 2 | País | 4° ARBITRO | ASESOR DE ARBITROS | País | ||
| 1 |
22-sep 19:00 |
Bogotá | DEPORTES TOLIMA (COL) | vs | SPORTIVO LUQUEÑO (PAR) | GERMAN DELFINO | HERNAN MAIDANA | ARIEL SCIME | ARG | WILSON LAMOUROUX | DEMVER PERDOMO | COL |
| 2 |
23-sep 17:00 |
Manta | EMELEC (ECU) | vs | INDEPENDIENTE SANTA FE (COL) | RICARDO MARQUES | RODRIGO CORREA | FABRICIO VILARINHO | BRA | CARLOS ORBE | JUAN COROZO | ECU |
| 3 |
23-sep 19:00 |
Buenos Aires | RIVER PLATE (ARG) | vs | LDU QUITO (ECU) | CHRISTIAN FERREYRA | MIGUEL NIEVAS | GABRIEL POPOVITS | URU | DIEGO CEBALLOS | MIGUEL SCIME | ARG |
| 4 |
23-sep 21:15 |
Buenos Aires | INDEPENDIENTE (ARG) | vs | OLIMPIA (PAR) | HEBER LOPES | GUILHERME CAMILO | CLERISTON BARRETO | BRA | PABLO DIAZ | CARLOS CORADINA | ARG |
| 5 |
23-sep 22:00 |
Recife | SC RECIFE (BRA) | vs | HURACAN (ARG) | ADRIAN VELEZ | ALEXANDER GUZMAN | WILMAR NAVARRO | COL | DEWSON FREITAS | MILTON OTAVIANO | BRA |
| 6 |
23-sep 22:00 |
Curitiba | ATL. PARANAENSE (BRA) | vs | BRASILIA FC (BRA) | GERY VARGAS | JAVIER BUSTILLOS | EDWIN PAREDES | BOL | RAPHAEL CLAUS | ROBERTO PERASSI | BRA |
| 7 |
24-sep 20:00 |
Asunción | LIBERTAD (PAR) | vs | CHAPECOENSE (BRA) | ROBERTO TOBAR | CHRISTIAN SCHIEMANN | CLAUDIO RIOS | CHI | CARLOS AMARILLA | UBALDO AQUINO | PAR |
| 8 |
24-sep 21:00 |
Buenos Aires | LANUS (ARG) | vs | DEFENSOR SPORTING (URU) | JOSE ARGOTE | LUIS SANCHEZ | TULIO MORENO | VEN | JORGE BALIÑO | LUIS PASTURENZI | ARG |
